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Wednesday, 20 June 2012 08:41
Bert passed away peacefully surrounded by love at the age of 82 on Friday June 15, 2012.
Dear husband of Helene Paquin, father of Timothy, Suzanne and Jane. Devoted grandfather to Caroline and Meghan Pollock. Loving brother and uncle to a large extended family. Predeceased by sons Joseph (2012) and Thomas (1969), and June (nee Thomas) (1991). Bert had a diverse and long career in engineering and management throughout Canada. After retiring in Medicine Hat, volunteering became his new venture. Bert was active in Kiwanis, St. Vincent de Paul among many other organizations. There will be a memorial mass on Thursday, June 21, 2012 at 11 am at St.Lukes Catholic Parish, 1566 Northmount Drive NW, Calgary, Alberta. Reception to follow. As expressions of sympathy, donations may be made to the Canadian Mental Health Association 400,105 -12 Ave SE, Calgary, AB T2G 1A1. Messages of condolence may be left for the family at www.myalternatives.ca.
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HealthDay Reporter WEDNESDAY, Oct. 25 (HealthDay News) -- The drug sildenafil, popularly known as Viagra, may help people with chronic obstructive pulmonary disease control the illness-related blood pressure spikes in the heart's pulmonary artery, a new study found.
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Phosphodiesterase-5 (PDE5) inhibitors (sildenafil, tadalafil, and vardenafil) are agents currently in clinical use for nonmalignant conditions. We report the use of PDE5 inhibitors as modulators of the antitumor immune response. In several mouse tumor models, PDE5 inhibition reverses tumor-induced immunosuppressive mechanisms and enables a measurable antitumor immune response to be generated that substantially delays tumor progression. In particular, sildenafil, down-regulates arginase 1 and nitric oxide synthaseľ2 expression, thereby reducing the suppressive machinery of CD11b+/Gr-1+ myeloid-derived suppressor cells (MDSCs) recruited by growing tumors. By removing these tumor escape mechanisms, sildenafil enhances intratumoral T cell infiltration and activation, reduces tumor outgrowth, and improves the antitumor efficacy of adoptive T cell therapy. Sildenafil also restores in vitro T cell proliferation of peripheral blood mononuclear cells from multiple myeloma and head and neck cancer patients. In light of the recent data that enzymes mediating MDSC-dependent immunosuppression in mice are active also in humans, these findings demonstrate a potentially novel use of PDE5 inhibitors as adjuncts to tumor-specific immune therapy.
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The study involved 285 patients with coronary artery disease who were divided into four groups: those with acute coronary syndrome and disease in one vessel; those with acute coronary syndrome and disease in two or three vessels; those with chronic coronary syndrome; and a control group of patients with suspected coronary artery disease but who were found by angiography to have normal coronary arteries.
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Investigation Physical examination, color duplex ultrasound of the penis and perineal area and Sexual Health Index for Men questionnaire.
Main outcome measures: Erectile dysfunction was identified in men who reported having had trouble keeping an erection when they wanted to, a problem which persisted for at least one month over the previous year. Variables examined in multivariate logistic regression analyses included age, education, presence of cardiovascular disease and diabetes, and current alcohol and tobacco consumption.
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